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The biological effects of mutp53 on the regulation of the MVA pathway explain various cellular processes ranging from proliferation to fitness, or the regulation of the tumor microenvironment, all of them with functional relevance for tumorigenesis (Mullen et al., 2016

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For this proposed rule, in cases where the relative weight for a MS-LTC-DRG with 25 or more applicable LTCH cases would decrease by more than 10-percent in FY 2024 relative to FY 2023, we are proposing to limit the reduction to 10-percent